Efficacy and Safety of Appropriate Shocks and Antitachycardia Pacing in Transvenous and Subcutaneous Implantable Defibrillators: Analysis of All Appropriate Therapy in the PRAETORIAN Trial.

Journal: Circulation
Published Date: Nov 14, 2021

Abstract

BACKGROUND: The PRAETORIAN trial (A Prospective, Randomized Comparison of Subcutaneous and Transvenous Implantable Cardioverter Defibrillator Therapy) showed noninferiority of subcutaneous implantable cardioverter defibrillator (S-ICD) compared with transvenous implantable cardioverter defibrillator (TV-ICD) with regard to inappropriate shocks and complications. In contrast to TV-ICD, S-ICD cannot provide antitachycardia pacing for monomorphic ventricular tachycardia. This prespecified secondary analysis evaluates appropriate therapy and whether antitachycardia pacing reduces the number of appropriate shocks.

Authors

  • Reinoud E Knops
    Department of Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
  • Willeke van der Stuijt
    Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location AMC, The Netherlands (R.E.K., W.v.d.S., L.V.A.B., T.F.B., A.-F.B.E.Q., L.S., J.G.P.T., J.R.d.G., K.M.K., A.d.W., A.A.M.W., L.R.A.O.N.).
  • Peter Paul H M Delnoy
    Department of Cardiology, Isala Heart Centre, Zwolle, The Netherlands (P.P.H.M.D.).
  • Lucas V A Boersma
    Department of Cardiology, St Antonius Hospital, Nieuwegein, The Netherlands (L.V.A.B.).
  • Juergen Kuschyk
    First Department of Medicine, University Medical Center Mannheim, Germany (J.K.).
  • Mikhael F El-Chami
    Division of Cardiology Section of Electrophysiology, Emory University, Atlanta, GA (M.F.E.-C.).
  • Hendrik Bonnemeier
    Klinik für Innere Medizin III, Schwerpunkt Kardiologie und Angiologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Germany (H.B.).
  • Elijah R Behr
    St George's University of London, United Kingdom (E.R.B.).
  • Tom F Brouwer
    Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location AMC, The Netherlands (R.E.K., W.v.d.S., L.V.A.B., T.F.B., A.-F.B.E.Q., L.S., J.G.P.T., J.R.d.G., K.M.K., A.d.W., A.A.M.W., L.R.A.O.N.).
  • Stefan Kääb
    Department of Medicine I, Ludwig-Maximillians University Hospital, München, Germany (S.K.).
  • Suneet Mittal
    The Valley Health System, Ridgewood, NJ (S.M.).
  • Anne-Floor B E Quast
    Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location AMC, The Netherlands (R.E.K., W.v.d.S., L.V.A.B., T.F.B., A.-F.B.E.Q., L.S., J.G.P.T., J.R.d.G., K.M.K., A.d.W., A.A.M.W., L.R.A.O.N.).
  • Lonneke Smeding
    Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location AMC, The Netherlands (R.E.K., W.v.d.S., L.V.A.B., T.F.B., A.-F.B.E.Q., L.S., J.G.P.T., J.R.d.G., K.M.K., A.d.W., A.A.M.W., L.R.A.O.N.).
  • Jan G P Tijssen
    Department of Cardiology, Amsterdam University Medical Center, The Netherlands (J.G.P.T.).
  • Nick R Bijsterveld
    Department of Cardiology, Flevoziekenhuis, Almere, The Netherlands (N.R.B.).
  • Sergio Richter
    Department of Electrophysiology, Heart Center at University of Leipzig, Germany (S.R.).
  • Marc A Brouwer
    Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands (M.A.B.).
  • Joris R de Groot
    Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location AMC, The Netherlands (R.E.K., W.v.d.S., L.V.A.B., T.F.B., A.-F.B.E.Q., L.S., J.G.P.T., J.R.d.G., K.M.K., A.d.W., A.A.M.W., L.R.A.O.N.).
  • Kirsten M Kooiman
    Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location AMC, The Netherlands (R.E.K., W.v.d.S., L.V.A.B., T.F.B., A.-F.B.E.Q., L.S., J.G.P.T., J.R.d.G., K.M.K., A.d.W., A.A.M.W., L.R.A.O.N.).
  • Pier D Lambiase
    Office of the Director of Clinical Electrophysiology Research and Lead for Inherited Arrhythmia Specialist Services, University College London and Barts Heart Centre, United Kingdom (P.D.L.).
  • Petr Neuzil
    Department of Cardiology, Homolka Hospital, Prague, Czech Republic (P. Neuzil).
  • Kevin Vernooy
    Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC+), Maastricht, the Netherlands.
  • Marco Alings
    Department of Cardiology, Amphia Hospital, Breda, The Netherlands (M.A.).
  • Timothy R Betts
    Oxford Biomedical Research Centre, Oxford University Hospitals NHS Trust, United Kingdom (T.R.B.).
  • Frank A L E Bracke
    Department of Electrophysiology, Catharina Hospital Eindhoven, The Netherlands (F.A.L.E.B.).
  • Martin C Burke
    CorVita Science Foundation, Chicago, IL (M.C.B.).
  • Jonas S S G de Jong
    Department of Cardiology, OLVG, Amsterdam, The Netherlands (J.S.S.G.d.J.).
  • David J Wright
    Liverpool Heart and Chest Hospital, United Kingdom (D.J.W.).
  • Ward P J Jansen
    Department of Cardiology, Tergooi MC, Blaricum, The Netherlands (W.P.J.J.).
  • Zachary I Whinnet
    National Heart and Lung Institute, Imperial College London, United Kingdom (Z.I.W.).
  • Peter Nordbeck
    University and University Hospital Würzburg, Germany (P. Nordbeck).
  • Michael Knaut
    Heart Surgery, Heart Center Dresden, Carl Gustav Carus Medical Faculty, Dresden University of Technology, Germany (M.K.).
  • Berit T Philbert
    Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Denmark (B.T.P.).
  • Jurren M van Opstal
    Medical Spectrum Twente, Enschede, The Netherlands (J.M.v.O.).
  • Alexandru B Chicos
    Division of Cardiology, Northwestern Memorial Hospital, Northwestern University, Chicago, IL (A.B.C.).
  • Cornelis P Allaart
    Department of Cardiology, and Amsterdam Cardiovascular Sciences, Amsterdam UMC, Location VUMC, Amsterdam, The Netherlands (C.P.A.).
  • Alida E Borger van der Burg
    Medisch Centrum Leeuwarden, Leeuwarden, The Netherlands (A.E.B.v.d.B.).
  • Jude F Clancy
    Department of Internal Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT (J.F.C.).
  • Jose M Dizon
    Department of Medicine-Cardiology, Columbia University Irving Medical Center, New York (J.M.D.).
  • Marc A Miller
    Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, New York (M.A.M.).
  • Dmitry Nemirovsky
    Cardiac Electrophysiology Division, Department of Medicine, Englewood Hospital and Medical Center, NJ (D.N.).
  • Ralf Surber
    Department of Internal Medicine I, Jena University Hospital, Germany (R.S.).
  • Gaurav A Upadhyay
    Center for Arrhythmia Care, Heart and Vascular Institute, University of Chicago Pritzker School of Medicine, IL (G.A.U.).
  • Raul Weiss
    Division of Cardiovascular Medicine, College of Medicine, The Ohio State University, Columbus (R.W.).
  • Anouk de Weger
    Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location AMC, The Netherlands (R.E.K., W.v.d.S., L.V.A.B., T.F.B., A.-F.B.E.Q., L.S., J.G.P.T., J.R.d.G., K.M.K., A.d.W., A.A.M.W., L.R.A.O.N.).
  • Arthur A M Wilde
    European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD-Heart (P.D.L., A.A.M.W.).
  • Louise R A Olde Nordkamp
    Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location AMC, The Netherlands (R.E.K., W.v.d.S., L.V.A.B., T.F.B., A.-F.B.E.Q., L.S., J.G.P.T., J.R.d.G., K.M.K., A.d.W., A.A.M.W., L.R.A.O.N.).

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