Multiscale insights into cornuside's effects on NAFLD: A cross-disciplinary integrating bioinformatics, computational chemistry, and machine learning.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology
Published Date: Apr 26, 2025

Abstract

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a complex metabolic disorder involving intertwined signaling pathways, posing challenges for targeted therapeutic interventions. Cornus Fructus (CF), a traditional medicinal herb, holds potential for NAFLD treatment, with cornuside (COR) identified as its primary active component.

Authors

  • Gai Gao
    Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine, Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China; School of Pharmacy, Minzu University of China, Beijing 100081, China.
  • Xiaowei Zhang
  • Zhenzhen Wang
    Department of Nursing, Union Hospital, Fujian Medical University, 29 Xinquan Road, Gulou District, 350001, Fuzhou, China.
  • Jiangyan Xu
    Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine, Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China.
  • Jinghui Wang
    Shanxi Entry-Exit Inspection and Quarantine Bureau, Taiyuan, China.
  • Tongxiang Liu
    School of Pharmacy, Minzu University of China, Beijing 100081, China. Electronic address: tongxliu123@hotmail.com.
  • Zhishen Xie
    Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine, Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China. Electronic address: xiezhishen@hactcm.edu.cn.

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