AIMC Topic: Insulin Resistance
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Circulating epigenetic signatures classifying brain insulin resistance in humans.
Science translational medicine
Aug 6, 2025
Brain insulin action plays an important role in metabolic and cognitive health, but there is no biomarker available to assess brain insulin resistance in humans. Here, we developed a machine learning framework based on blood DNA methylation profiles ...
The value of triglyceride-glucose index-related indices in evaluating migraine: perspectives from multi-centre cross-sectional studies and machine learning models.
Lipids in health and disease
Jul 3, 2025
BACKGROUND: This study employed representative data from the U.S. and China to delve into the correlation among migraine prevalence, the triglyceride‒glucose index, a marker of insulin resistance, and the composite indicator of obesity.
In-silico guided identification and studies of potential FFAR4 agonists for type 2 diabetes mellitus therapy.
Expert opinion on drug discovery
Jun 28, 2025
BACKGROUND: The activation of free fatty acid receptor 4 (FFAR4) enhances insulin sensitivity and glucose uptake while mitigating inflammation. It is a promising therapeutic approach for managing type 2 diabetes mellitus (T2DM).
Lipidomic profiling of human adiposomes identifies specific lipid shifts linked to obesity and cardiometabolic risk.
JCI insight
Jun 23, 2025
BACKGROUNDObesity, a growing health concern, often leads to metabolic disturbances, systemic inflammation, and vascular dysfunction. Emerging evidence suggests that adipose tissue-derived extracellular vesicles (adiposomes) may propagate obesity-rela...
Development and validation of a LASSO logistic regression based nomogram for predicting live births in women with polycystic ovary syndrome: a retrospective cohort study.
Frontiers in endocrinology
May 27, 2025
OBJECTIVE: There is limited study on predictive models for live births in patients with polycystic ovarian syndrome (PCOS). The study aimed to develop and validate a nomogram for predicting live births in Chinese women with PCOS, as well as to identi...
Insulin resistance in type 1 diabetes is a key modulator of platelet hyperreactivity.
Diabetologia
Apr 30, 2025
AIMS/HYPOTHESIS: Individuals with type 1 diabetes are at increased cardiovascular risk, particularly in the presence of insulin resistance. A prothrombotic environment is believed to contribute to this risk but thrombotic pathways in type 1 diabetes ...
Multiscale insights into cornuside's effects on NAFLD: A cross-disciplinary integrating bioinformatics, computational chemistry, and machine learning.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Apr 26, 2025
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a complex metabolic disorder involving intertwined signaling pathways, posing challenges for targeted therapeutic interventions. Cornus Fructus (CF), a traditional medicinal herb, holds potenti...
Estimated glucose disposal rate outperforms other insulin resistance surrogates in predicting incident cardiovascular diseases in cardiovascular-kidney-metabolic syndrome stages 0-3 and the development of a machine learning prediction model: a nationwide prospective cohort study.
Cardiovascular diabetology
Apr 16, 2025
BACKGROUND: The American Heart Association recently introduced the concept of cardiovascular-kidney-metabolic (CKM) syndrome, highlighting the increasing importance of the complex interplay between metabolic, renal, and cardiovascular diseases (CVD)....
China
Blood Glucose
Incidence
Time Factors
Metabolic Syndrome
Male
Humans
Kidney Diseases
Decision Support Techniques
Cardiovascular Diseases
Machine Learning
Predictive Value of Tests
Prognosis
Insulin Resistance
Middle Aged
Prospective Studies
Female
Risk Assessment
Longitudinal Studies
Biomarkers
Risk Factors
Aged
Surrogate markers of insulin resistance and coronary artery disease in type 2 diabetes: U-shaped TyG association and insights from machine learning integration.
Lipids in health and disease
Mar 15, 2025
BACKGROUND: Surrogate insulin resistance (IR) indices are simpler and more practical alternatives to insulin-based IR indicators for clinical use. This study explored the association between surrogate IR indices, including triglyceride-glucose index ...
Circulating CCN6/WISP3 in type 2 diabetes mellitus patients and its correlation with insulin resistance and inflammation: statistical and machine learning analyses.
BMC medical informatics and decision making
Mar 6, 2025
INTRODUCTION: Cellular Communication Network Factor 6 (CCN6) is an adipokine whose production undergoes significant alterations in metabolic disorders. Given the well-established link between obesity-induced adipokine dysfunction and the development ...
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