BACKGROUND: Fatty liver disease is a common condition linked to metabolic syndrome, cardiovascular diseases, and liver cirrhosis, and timely, accurate diagnosis is crucial. In clinical studies, incorporating deep learning models often faces the chall...
The aim of this study was to develop a combined deep-learning model utilizing liver ultrasound, liver elastography images, and clinical features to predict and diagnose fibrotic non-alcoholic steatohepatitis (NASH). A rat model of liver steatosis and...
Type 2 diabetes mellitus (T2DM) and metabolism-associated fatty liver disease (MAFLD) are prevalent metabolic disorders with shared pathophysiological mechanisms. A comprehensive understanding of the molecular pathways involved in their onset and pro...
BACKGROUND: Considering the complex and close-knit relationship between non-alcoholic fatty liver disease (NAFLD) and the metabolic status, this study aimed to identify lipid metabolism-related genes (LMGs), construct an effective diagnostic model, a...
Machine learning studies for Raman imaging have addressed the differentiability of normal and diseased states in biomedical applications by grouping a set of Raman spectra in terms of spectral similarity over the sample. However, Raman imaging provid...
Metabolic dysfunction-associated fatty liver disease (MAFLD), a global epidemic affecting 25% of adults, is driven by immune-metabolic dysregulation, yet the causal mechanisms linking immune cell-specific gene perturbations to disease progression rem...
This study employed machine learning models to quantitatively analyze liver fat content from MRI images for the evaluation of liver fibrosis and disease severity in patients with metabolic dysfunction-associated fatty liver disease (MAFLD). A total o...
Nonalcoholic fatty liver disease (NAFLD) is emerging as the leading cause of chronic liver disease in many regions, particularly in association with the rising prevalence of Metabolic syndrome (MetS), affecting more than 30% of the population worldwi...
Steatotic liver disease (SLD), formerly named fatty liver disease, has a prevalence estimated at 30-38% in adults. Detection of SLD is important, since prompt initiation of treatment can stop disease progression, lead to a reduction in adverse outcom...
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Jul 22, 2025
This study explores the therapeutic targets and mechanisms of Gynostemma pentaphyllum in non-alcoholic fatty liver disease (NAFLD). Using network analysis and bioinformatics, we identified target genes of Gynostemma's active metabolites in NAFLD thro...
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