Response prediction for neoadjuvant treatment in locally advanced rectal cancer patients-improvement in decision-making: A systematic review.

Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Published Date: Nov 15, 2024

Abstract

BACKGROUND: Predicting pathological complete response (pCR) from pre or post-treatment features could be significant in improving the process of making clinical decisions and providing a more personalized treatment approach for better treatment outcomes. However, the lack of external validation of predictive models, missing in several published articles, is a major issue that can potentially limit the reliability and applicability of predictive models in clinical settings. Therefore, this systematic review described different externally validated methods of predicting response to neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC) patients and how they could improve clinical decision-making.

Authors

  • Luca Boldrini
    Radiation Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Diepriye Charles-Davies
    Radiomics Core Research Facility, Gemelli Science and Technology Park, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy. Electronic address: charlesdavies.diepriye@policlinicogemelli.it.
  • Angela Romano
    Fondazione Policlinico Universitario ''Agostino Gemelli'' IRCCS, Rome, Italy.
  • Matteo Mancino
    Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Department of Diagnostic Imaging, Oncological Radiotherapy and Hematology, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Ilaria Nacci
  • Huong Elena Tran
    Radiomics G-STeP Research Core Facility, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
  • Francesco Bono
    Radiomics Core Research Facility, Gemelli Science and Technology Park, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
  • Edda Boccia
    Radiomics Core Research Facility, Gemelli Science and Technology Park, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
  • Maria Antonietta Gambacorta
    Fondazione Policlinico Universitario ''Agostino Gemelli'' IRCCS, Rome, Italy.
  • Giuditta Chiloiro
    Fondazione Policlinico Universitario ''Agostino Gemelli'' IRCCS, Rome, Italy.

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