AIMC Topic: Chemoradiotherapy

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Revolutionizing cervical cancer care: the synergistic effects of hyperthermia and machine learning.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
OBJECTIVE: This study aimed to examine the impact of hyperthermia in conjunction with concurrent chemoradiotherapy (CCRT) on peripheral immune markers in patients with locally advanced cervical cancer (LACC). Additionally, we sought to predict the as...

Gut microbiota predictive of the efficacy of consolidation immunotherapy and chemoradiotherapy toxicity in lung cancer.

Med (New York, N.Y.)
BACKGROUND: Gut microbiota (GM) predict responses to immune checkpoint inhibitors (ICIs) in patients with advanced lung cancer. However, its role in patients with locally advanced lung cancer undergoing chemoradiotherapy (CRT) combined with consolida...

Predicting hematologic toxicity in advanced cervical cancer patients using interpretable machine learning models based on radiomics and dosimetrics.

BMC cancer
BACKGROUND AND OBJECTIVES: Hematologic toxicity (HT) is a common and serious side effect for advanced cervical cancer patients undergoing chemoradiotherapy. Accurately predicting HT can significantly improve patient management and treatment outcomes....

Development and validation of machine-learning model based on dynamic tumor markers in predicting pathological complete response after neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer: a multicenter cohort study.

International journal of colorectal disease
OBJECTIVE: In this study, we constructed a new pCR predictor based on dynamic tumor marker changes before and after NCRT, the dynamic tumor marker score (DTMS), and combined it with other clinicopathological features to build a machine-learning model...

Genetic algorithm-optimized neural network outperforms TNM staging in predicting rapidly progressive nasopharyngeal carcinoma: Reassessing adjuvant chemotherapy benefit via propensity score matching.

European journal of cancer (Oxford, England : 1990)
PURPOSE: To establish machine learning-based predictive models for rapidly progressive nasopharyngeal carcinoma (RP-NPC), defined as disease progression within 24 months post-initial treatment, and to assess differential survival benefits of adjuvant...

External validation of deep learning-derived 18F-FDG PET/CT delta biomarkers for loco-regional control in head and neck cancer.

Acta oncologica (Stockholm, Sweden)
BACKGROUND AND PURPOSE: Delta biomarkers that reflect changes in tumour burden over time can support personalised follow-up in head and neck cancer. However, their clinical use can be limited by the need for manual image segmentation. This study exte...

Impact of large language models and vision deep learning models in predicting neoadjuvant rectal score for rectal cancer treated with neoadjuvant chemoradiation.

BMC medical imaging
This study aims to explore Deep Learning methods, namely Large Language Models (LLMs) and Computer Vision models to accurately predict neoadjuvant rectal (NAR) score for locally advanced rectal cancer (LARC) treated with neoadjuvant chemoradiation (N...

Cone-beam computed tomography-based online adaptive radiotherapy of esophageal cancer in the neoadjuvant setting: Dosimetric analysis, toxicity and treatment response.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
BACKGROUND AND PURPOSE: Chemoradiotherapy (CRT) followed by surgery is a treatment option for esophageal cancer (EC). However, concerns persist regarding cardiopulmonary toxicity and inconsistent daily target coverage due to anatomical changes. To ad...

Radiomic analysis based on machine learning of multi-sequences MR to assess early treatment response in locally advanced nasopharyngeal carcinoma.

Science progress
ObjectiveThe prediction of early response in locally advanced nasopharyngeal carcinoma (LA-NPC) after concurrent chemoradiotherapy (CCRT) is important for determining the need for timely consolidation therapy. We developed a radiomic analysis of mult...

Deep Learning Model of Primary Tumor and Metastatic Cervical Lymph Nodes From CT for Outcome Predictions in Oropharyngeal Cancer.

JAMA network open
IMPORTANCE: Primary tumor (PT) and metastatic cervical lymph node (LN) characteristics are highly associated with oropharyngeal squamous cell carcinoma (OPSCC) prognosis. Currently, there is a lack of studies to combine imaging characteristics of bot...