Assessment of the transmission of live-attenuated chikungunya virus vaccine VLA1553 by Aedes albopictus mosquitoes.

Journal: Parasites & vectors
PMID: 40355954

Abstract

BACKGROUND: Chikungunya virus (CHIKV) is a mosquito-transmitted, arthritogenic alphavirus that causes sporadic outbreaks of often debilitating rheumatic disease. The recently approved CHIKV vaccine, IXCHIQ, is based on a live-attenuated CHIKV strain (VLA1553), with viraemic vaccine recipients theoretically able to transmit VLA1553 to mosquitoes with ensuing onward transmission. We thus evaluated VLA1553 transmission from artificial blood meals to Aedes albopictus mosquitoes, and onward transmission to mice.

Authors

  • Andrea Fritzer
    Valneva Austria GmbH, Campus Vienna Biocenter 3, 1030, Vienna, Austria. Andrea.FRITZER@valneva.com.
  • Andreas Suhrbier
    Inflammation Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4029, Australia.
  • Leon E Hugo
    Mosquito Control, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4029, Australia.
  • Bing Tang
    School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou, 510006, PR China. Electronic address: tang@gdut.edu.cn.
  • Greg Devine
    Mosquito Control, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4029, Australia.
  • Sandra Jost
    Valneva Austria GmbH, Campus Vienna Biocenter 3, 1030, Vienna, Austria.
  • Andreas L Meinke
    Valneva Austria GmbH, Campus Vienna Biocenter 3, 1030, Vienna, Austria.

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