Unraveling the oxidative stress landscape in diabetic foot ulcers: insights from bulk RNA and single-cell RNA sequencing data.

Journal: Biology direct
Published Date: Jul 4, 2025

Abstract

BACKGROUND: Oxidative stress plays a crucial role in the development of diabetic foot ulcers (DFU). However, its underlying mechanisms are not fully understood. The purpose of this study was to use bioinformatics and preliminary validation methods to preliminarily reveal the oxidative stress landscape in DFU.

Authors

  • Jialiang Lin
    Department of Orthopaedics, Fengxian District Central Hospital, No. 6600 Nanfeng Road, Shanghai, 201499, China.
  • Linjuan Huang
    Department of Orthopaedics, Fengxian District Central Hospital, No. 6600 Nanfeng Road, Shanghai, 201499, China.
  • Weiming Li
    Shanghai Nuanhe Brain Technology Co., Ltd, Shanghai, China.
  • Haijun Xiao
    Department of Orthopaedics, Fengxian District Central Hospital, No. 6600 Nanfeng Road, Shanghai, 201499, China. xiaohaijun89@163.com.
  • Mingmang Pan
    Department of Orthopaedics, Fengxian District Central Hospital, No. 6600 Nanfeng Road, Shanghai, 201499, China. lighting2013@foxmail.com.

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