Association Between COVID-19 During Pregnancy and Preterm Birth by Trimester of Infection: Retrospective Cohort Study Using Large-Scale Social Media Data.

Journal: Journal of medical Internet research
Published Date: Jul 9, 2025

Abstract

BACKGROUND: Preterm birth, defined as birth at <37 weeks of gestation, is the leading cause of neonatal death globally and the second leading cause of infant mortality in the United States. There is mounting evidence that COVID-19 infection during pregnancy is associated with an increased risk of preterm birth; however, data remain limited by trimester of infection. The ability to study COVID-19 infection during the earlier stages of pregnancy has been limited by available sources of data.

Authors

  • Ari Z Klein
    Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Shriya Kunatharaju
    Department of Genetics, University of Pennsylvania, Philadelphia, PA, United States.
  • Su Golder
    Department of Health Sciences, University of York, York, United Kingdom.
  • Lisa D Levine
    Maternal Fetal Medicine Research Program, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
  • Jane C Figueiredo
    Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
  • Graciela Gonzalez-Hernandez
    Health Language Processing Center, Institute for Biomedical Informatics at the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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