A novel machine-learning algorithm to screen for trisomy 21 in first-trimester singleton pregnancies.
Journal:
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
Published Date:
Jul 9, 2025
Abstract
BACKGROUND: Antenatal screening for Trisomy 21 (T21) in the UK is performed primarily in the first trimester. Nuchal Translucency (NT), gestational age, Free β-HCG and PAPP-A are used in combination, creating the 'combined' test. Multivariate Gaussian distribution models then determine the chance of T21 expressed as an odds ratio. This study investigates the use of machine-learning algorithms in the prediction of T21 in first-trimester singleton pregnancies and compares their performance to existing screening models.
