AIMC Topic: Pregnancy-Associated Plasma Protein-A

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Raised Leptin and Pappalysin2 cell-free RNAs are the hallmarks of pregnancies complicated by preeclampsia with fetal growth restriction.

Nature communications Jul 18, 2025
Preeclampsia (PE) and fetal growth restriction (FGR) complicate 5-10% of pregnancies and are major causes of maternal and fetal morbidity and mortality. Here we demonstrate that measuring circulating cell-free RNAs (cfRNAs) from maternal plasma can a...
Humans Machine Learning Biomarkers Pregnancy Female Adult Case-Control Studies ROC Curve Cell-Free Nucleic Acids Proteoglycans Leptin Pre-Eclampsia Fetal Growth Retardation Pregnancy-Associated Plasma Protein-A
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A novel machine-learning algorithm to screen for trisomy 21 in first-trimester singleton pregnancies.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology Jul 9, 2025
BACKGROUND: Antenatal screening for Trisomy 21 (T21) in the UK is performed primarily in the first trimester. Nuchal Translucency (NT), gestational age, Free β-HCG and PAPP-A are used in combination, creating the 'combined' test. Multivariate Gaussia...
Humans Machine Learning Algorithms Pregnancy Female Adult Pregnancy Trimester, First Down Syndrome False Positive Reactions Gestational Age Prenatal Diagnosis Nuchal Translucency Measurement Chorionic Gonadotropin, beta Subunit, Human Pregnancy-Associated Plasma Protein-A
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Development and Validation of a Deep Learning Model to Screen for Trisomy 21 During the First Trimester From Nuchal Ultrasonographic Images.

JAMA network open Jun 1, 2022
IMPORTANCE: Accurate screening of trisomy 21 in the first trimester can provide an early opportunity for decision-making regarding reproductive choices.
Humans Biomarkers Pregnancy Female Adult Infant Deep Learning Pregnancy Trimester, First Down Syndrome Prenatal Diagnosis Chorionic Gonadotropin, beta Subunit, Human Trisomy Pregnancy-Associated Plasma Protein-A
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