AIMC Topic: Pregnancy-Associated Plasma Protein-A

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XGBoost-based analysis of maternal and biochemical factors associated with spontaneous preterm birth: a retrospective cohort study.

BMC pregnancy and childbirth Nov 18, 2025
BACKGROUND: Spontaneous preterm birth (sPTB) remains a major cause of neonatal morbidity and early risk assessment was poor. This study aimed to evaluate the association and predictive potential of serum biomarkers and maternal factors with sPTB.
Risk Factors Adult Female Premature Birth Logistic Models alpha-Fetoproteins Boosting Machine Learning Algorithms Risk Assessment China Humans Retrospective Studies Pregnancy Biomarkers Chorionic Gonadotropin, beta Subunit, Human Pregnancy-Associated Plasma Protein-A
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Raised Leptin and Pappalysin2 cell-free RNAs are the hallmarks of pregnancies complicated by preeclampsia with fetal growth restriction.

Nature communications Jul 18, 2025
Preeclampsia (PE) and fetal growth restriction (FGR) complicate 5-10% of pregnancies and are major causes of maternal and fetal morbidity and mortality. Here we demonstrate that measuring circulating cell-free RNAs (cfRNAs) from maternal plasma can a...
Pregnancy-Associated Plasma Protein-A Pre-Eclampsia Fetal Growth Retardation Proteoglycans Leptin Female Adult ROC Curve Cell-Free Nucleic Acids Case-Control Studies Humans Machine Learning Biomarkers Pregnancy
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A novel machine-learning algorithm to screen for trisomy 21 in first-trimester singleton pregnancies.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology Jul 9, 2025
BACKGROUND: Antenatal screening for Trisomy 21 (T21) in the UK is performed primarily in the first trimester. Nuchal Translucency (NT), gestational age, Free β-HCG and PAPP-A are used in combination, creating the 'combined' test. Multivariate Gaussia...
Gestational Age Prenatal Diagnosis Chorionic Gonadotropin, beta Subunit, Human Pregnancy-Associated Plasma Protein-A Nuchal Translucency Measurement Down Syndrome False Positive Reactions Adult Pregnancy Trimester, First Algorithms Humans Pregnancy Machine Learning Female
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Determining the risk of gestational diabetes using machine learning: A study on first-trimester PAPP-A and β-hCG data.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Jun 2, 2025
OBJECTIVE: To evaluate the predictive potential of first-trimester biomarkers-pregnancy-associated plasma protein-A (PAPP-A) and free β-human chorionic gonadotropin (β-hCG)-combined with maternal body mass index (BMI), using machine learning (ML) alg...
Algorithms ROC Curve Humans Biomarkers Body Mass Index Machine Learning Pregnancy Adult Diabetes, Gestational Female Risk Assessment Retrospective Studies Chorionic Gonadotropin, beta Subunit, Human Pregnancy-Associated Plasma Protein-A Predictive Value of Tests Pregnancy Trimester, First
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Development and Validation of a Deep Learning Model to Screen for Trisomy 21 During the First Trimester From Nuchal Ultrasonographic Images.

JAMA network open Jun 1, 2022
IMPORTANCE: Accurate screening of trisomy 21 in the first trimester can provide an early opportunity for decision-making regarding reproductive choices.
Trisomy Pregnancy-Associated Plasma Protein-A Adult Prenatal Diagnosis Pregnancy Infant Humans Chorionic Gonadotropin, beta Subunit, Human Female Pregnancy Trimester, First Biomarkers Down Syndrome Deep Learning
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