Machine learning diagnosis of cognitive impairment and dementia in harmonized older adult cohorts.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
Published Date: Aug 1, 2025

Abstract

INTRODUCTION: Clinical diagnosis (normal cognition, mild cognitive impairment [MCI], dementia) is critical for understanding cognitive impairment and dementia but can be resource intensive and subject to inconsistencies due to complex clinical judgments that are required. Machine learning approaches might provide meaningful additions and/or alternatives to traditional clinical diagnosis.

Authors

  • Dan Mungas
    Department of Neurology, UC Davis School of Medicine, Sacramento, California, USA.
  • Brandon Gavett
    Department of Neurology, UC Davis School of Medicine, Sacramento, California, USA.
  • L Paloma Rojas-Saunero
    Department of Epidemiology, University of California Los Angeles Fielding School of Public Health, Los Angeles, California, USA.
  • Yixuan Zhou
    Department of Epidemiology, University of California Los Angeles Fielding School of Public Health, Los Angeles, California, USA.
  • Eleanor Hayes-Larson
    Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
  • Crystal Shaw
    Oncology Department, Amgen, Inc., Thousand Oaks, California, USA.
  • Sarah Tomaszewski Farias
    Department of Neurology, UC Davis School of Medicine, Sacramento, California, USA.
  • Keith Widaman
    School of Education and Graduate Division, University of California Riverside, Riverside, California, USA.
  • Evan Fletcher
    Department of Neurology, UC Davis School of Medicine, Sacramento, California, USA.
  • Maria M Corrada
    Department of Neurology, University of California Irvine School of Medicine, Orange, California, USA.
  • Paola Gilsanz
    Northern California Division of Research, Kaiser Permanente, Pleasanton, California, USA.
  • Maria Glymour
    Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
  • John Olichney
    Department of Neurology, UC Davis School of Medicine, Sacramento, California, USA.
  • Charles DeCarli
    Department of Neurology, University of California-Davis School of Medicine, 4860 Y Street Suite 3700, Sacramento, CA, 95817, USA.
  • Rachel Whitmer
    Department of Neurology, UC Davis School of Medicine, Sacramento, California, USA.
  • Elizabeth Rose Mayeda
    Department of Epidemiology, University of California Los Angeles Fielding School of Public Health, Los Angeles, California, USA.

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