Dynamic identifying protein functional modules based on adaptive density modularity in protein-protein interaction networks.
Journal:
BMC bioinformatics
Published Date:
Aug 25, 2015
Abstract
BACKGROUND: The identification of protein functional modules would be a great aid in furthering our knowledge of the principles of cellular organization. Most existing algorithms for identifying protein functional modules have a common defect -- once a protein node is assigned to a functional module, there is no chance to move the protein to the other functional modules during the follow-up processes, which lead the erroneous partitioning occurred at previous step to accumulate till to the end.