Comprehensive analysis of single-cell and bulk transcriptome unravels immune landscape of atherosclerosis and develops a S100 family based-diagnostic model.

Journal: Computational biology and chemistry
Published Date:

Abstract

BACKGROUND: The S100 family of calcium-binding proteins (S100s) had been tightly related to the biological processes of various cardiovascular diseases. This study aims to investigate the expression of S100s in Atherosclerosis (AS) and explore their potential as diagnostic biomarkers and therapeutic targets.

Authors

  • Yanfei Mo
    Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; Department of Cardiology, Pukou Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, China; Jiangsu Medical College, Yancheng, Jiangsu, China.
  • Yaoqi Ge
    Department of General Practice, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
  • Dan Wang
    Guangdong Pharmaceutical University Guangzhou Guangdong China.
  • Jizheng Wang
    Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
  • Rihua Zhang
    Department of the Core Facility, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
  • Yifang Hu
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, JiangsuĀ 210029, China.
  • Xiaoxuan Qin
    Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
  • Yanyan Hu
    Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
  • Shan Lu
    The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Yun Liu
    Google Health, Palo Alto, CA USA.
  • Wen-Song Zhang
    Department of the Core Facility, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address: zhangwensong91@126.com.