Identification of a novel hypermethylation marker, ZSCAN18, and construction of a diagnostic model in cervical cancer.

Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Published Date: Feb 19, 2025

Abstract

PURPOSE: Cervical cancer (CC), a common female malignancy, has been linked to alterations in DNA methylation. This study employed an integrated "dry-wet lab" strategy combining bioinformatics, machine learning, and experimental validation to identify novel methylation biomarkers for CC.

Authors

  • Jinhao Yang
    Department of Laboratory Medicine, School of Medical Technology, Tianjin Medical University, Tianjin, 300203, China.
  • Shuang Chen
    The Beijing Genomics Institute (BGI), Shenzhen 518083, China. chenss@connect.hku.hk.
  • Yuqing Liu
    School of Data Science, City University of Hong Kong, Kowloon, Hong Kong. Electronic address: yuqinliu6-c@my.cityu.edu.hk.
  • Ping Wang
    School of Chemistry and Chemical Engineering, Shandong University of Technology, 255049, Zibo, PR China. Electronic address: wangping876@163.com.
  • Jing Zhao
    Department of Pharmacy, Pharmacoepidemiology and Drug Safety Research Group, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
  • Jianying Yi
    Department of Clinical Laboratory, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, 300192, China.
  • Jin Wei
    Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, No. 100 Haining Road, Shanghai 20080, PR China.
  • Rong Wang
    College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shanxi, China. Electronic address: wangrong91@nwsuaf.edu.cn.

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