Machine learning algorithms integrate bulk and single-cell RNA data to reveal the crosstalk and heterogeneity of NOTCH and autophagy activity following idiopathic pulmonary fibrosis.

Journal: International immunopharmacology
Published Date: Jun 9, 2025

Abstract

BACKGROUND: NOTCH and autophagy significantly impact the pathogenesis of idiopathic pulmonary fibrosis (IPF); however, studies exploring their heterogeneity and potential correlation at the single-cell level are still lacking. Identifying the feature genes that are commonly regulated by both NOTCH and autophagy could significantly increase our understanding of IPF.

Authors

  • Zhichuang Lian
    Department of Respiratory and Critical Care Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China; Xinjiang Clinical Medical Research Center for Respiratory Diseases, Urumqi 830001, China.
  • Jingran Xu
    Department of Clinical Research Center of Infectious Diseases (Pulmonary Tuberculosis), First People's Hospital of Kashi, Kashi, China.
  • Sumanye Maolahong
    Department of Respiratory and Critical Care Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China; Xinjiang Clinical Medical Research Center for Respiratory Diseases, Urumqi 830001, China.
  • Yina Ha
    Department of Respiratory and Critical Care Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China; Xinjiang Clinical Medical Research Center for Respiratory Diseases, Urumqi 830001, China.
  • Maheliya Hasimujiang
    Department of Respiratory and Critical Care Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China; Xinjiang Clinical Medical Research Center for Respiratory Diseases, Urumqi 830001, China.
  • Mailidan Maimaitiniyazi
    Department of Respiratory and Critical Care Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China; Xinjiang Clinical Medical Research Center for Respiratory Diseases, Urumqi 830001, China.
  • Chao Wu
  • Liping Chen
    Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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