AIMC Topic: Receptors, Notch

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Machine learning algorithms integrate bulk and single-cell RNA data to reveal the crosstalk and heterogeneity of NOTCH and autophagy activity following idiopathic pulmonary fibrosis.

International immunopharmacology
BACKGROUND: NOTCH and autophagy significantly impact the pathogenesis of idiopathic pulmonary fibrosis (IPF); however, studies exploring their heterogeneity and potential correlation at the single-cell level are still lacking. Identifying the feature...

Identification of KCNQ1 as a diagnostic biomarker related to endoplasmic reticulum stress for intervertebral disc degeneration based on machine learning and experimental evidence.

Medicine
Intervertebral disc degeneration (IDD) is a primary cause of low back pain and disability. Cellular senescence and apoptosis due to endoplasmic reticulum stress (ERS) are key in IDD pathology. Identifying biomarkers linked to ERS in IDD is crucial fo...