From correlation to causation: unraveling the role of long non-coding RNAs in COVID-19 pathogenesis.

Journal: Virology journal
Published Date: Aug 28, 2025

Abstract

Heydari et al. present an intriguing study examining the role of three long non-coding RNAs (lncRNAs)-H19, taurine upregulated gene 1 (TUG1), and colorectal neoplasia differentially expressed (CRNDE)-in the context of Coronavirus Disease 2019 (COVID-19), focusing on their diagnostic potential and biological significance. The authors argue that these lncRNAs play a role in inflammatory and fibrotic processes associated with COVID-19 and demonstrate their potential utility as biomarkers using machine learning-based predictive models. While the study offers significant contributions to the field, there are limitations in its methodology, interpretative depth, and generalizability that merit closer examination. This commentary critically evaluates the findings, suggesting avenues for refinement and further research.

Authors

  • Tianfei Yu
    Department of Biotechnology, College of Life Science and Agriculture and Forestry, Qiqihar University, Qiqihar 161006, China.
  • Yunhan Zhang
    Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang, 110819, China; National Frontiers Science Center for Industrial Intelligence and Systems Optimization, Northeastern University, Shenyang, 110819, China; Key Laboratory of Data Analytics and Optimization for Smart Industry, Northeastern University, Ministry of Education, Shenyang, 110819, China.
  • Haolan Zhang
    Department of Biotechnology, College of Life Science and Agriculture Forestry, Qiqihar University, Qiqihar, 161006, China.
  • Ming Li
    Radiology Department, Huadong Hospital, Affiliated with Fudan University, Shanghai, China.

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