Integrative analysis of transcriptome and metabolome profiles reveals immune-metabolic alterations in pulmonary sarcoidosis.

Journal: Metabolomics : Official journal of the Metabolomic Society
Published Date: Aug 29, 2025

Abstract

BACKGROUND: Pulmonary sarcoidosis, a disease of unknown etiology, is characterized by the presence of noncaseating granulomas in lung parenchyma. This present study combines metabolomic and transcriptomic data to determine the metabolic and differentially expressed genes (DEGs) and associated pathways in sarcoidosis patients as compared to healthy controls. It is envisioned that a better understanding of the underlying mechanism will help in diagnosis and future treatment strategies.

Authors

  • Sanjukta Dasgupta
    Department of Biotechnology, Brainware University, Barasat, India.
  • Priyanka Choudhury
    School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, 721302, India.
  • Sankalp Patidar
  • Mamata Joshi
    National Facility for High-field NMR, Tata Institute of Fundamental Research, Mumbai, India.
  • Riddhiman Dhar
    Department of Biotechnology, IIT Kharagpur, Kharagpur, West Bengal, 721302, India. riddhiman.dhar@iitkgp.ac.in.
  • Sushmita Roychowdhury
    Fortis Hospital Anandapur, Kolkata, India.
  • Parthasarathi Bhattacharyya
    Institute of Pulmocare and Research, Kolkata, Kolkata 700064, India. Electronic address: parthachest@yahoo.com.
  • Koel Chaudhury

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