Epistasis analysis using multifactor dimensionality reduction.
Journal:
Methods in molecular biology (Clifton, N.J.)
Published Date:
Jan 1, 2015
Abstract
Here we introduce the multifactor dimensionality reduction (MDR) methodology and software package for detecting and characterizing epistasis in genetic association studies. We provide a general overview of the method and then highlight some of the key functions of the open-source MDR software package that is freely distributed. We end with a few examples of published studies of complex human diseases that have used MDR.