OBJECTIVE: Muscle-invasive bladder cancer (MIBC) is a highly aggressive disease with a poor prognosis. This study aims to explore the correlation between the spatial distribution of lymphocyte aggregates and the prognosis of MIBC using deep learning.
This work introduces a hybrid computational approach in which degree-based topological descriptors are harnessed with the aid of advanced regression models and artificial neural networks (ANNs) to predict the crucial physicochemical properties of 17 ...
Bladder cancer (BLCA) is a prevalent urological malignancy that exhibits a high degree of tumor heterogeneity and morbidity. Tumor angiogenesis, a vital hallmark of cancer, greatly influences the tumor microenvironment (TME). The emergence of anti-an...
The development of bladder cancer (BLCA) is associated with mitochondrial dysfunction and neutrophil extracellular traps (NETs); however, the relationship between mitochondrial function and NET formation in BLCA remains poorly understood. In this stu...
BACKGROUND AND OBJECTIVE: Radical cystectomy (RC) is associated with a high risk of postoperative complications. The prediction of individual patient risk for severe complications can facilitate preoperative shared decision-making. Patients with elev...
Intravesical drug instillation is a common treatment for bladder cancer, but it suffers from poor targeting and suboptimal patient experience due to the influence of gravity. Here, we innovatively designed a bladder cancer treatment method using sodi...
Urethral recurrence (UR) following radical cystectomy for bladder cancer represents an aggressive disease failure with typically poor survival outcomes. Our study aimed to assess the predictive risk factors for UR, to develop and validate an easy-to-...
BACKGROUND: Preoperative diagnosis of muscle invasion and American Joint Committee on Cancer (AJCC) stage plays a crucial role in guiding treatment strategies for bladder cancer (BCa). Utilizing quantitative analysis of tumor subregions via CT imagin...
Bladder cancer is the fourth most common malignant tumor in men, with limited therapeutic biomarkers and heterogeneous responses to immunotherapy. Disulfide bond-driven cell death has emerged as a critical regulator of tumor progression and immune mi...
The absence of specific markers makes early detection of bladder cancer (BC) challenging. Recent studies have reported the reliable diagnostic significance of volatile organic compounds (VOCs) in several cancers. This study aimed to investigate wheth...
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