Prediction of brain age suggests accelerated atrophy after traumatic brain injury.
Journal:
Annals of neurology
Published Date:
Apr 1, 2015
Abstract
OBJECTIVE: The long-term effects of traumatic brain injury (TBI) can resemble observed in normal ageing, suggesting that TBI may accelerate the ageing process. We investigate this using a neuroimaging model that predicts brain age in healthy individuals and then apply it to TBI patients. We define individuals' differences in chronological and predicted structural "brain age," and test whether TBI produces progressive atrophy and how this relates to cognitive function.