Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation.

Journal: Nature methods
Published Date: May 25, 2015

Abstract

We present a robot that enables high-content studies of alert adult Drosophila by combining operations including gentle picking; translations and rotations; characterizations of fly phenotypes and behaviors; microdissection; or release. To illustrate, we assessed fly morphology, tracked odor-evoked locomotion, sorted flies by sex, and dissected the cuticle to image neural activity. The robot's tireless capacity for precise manipulations enables a scalable platform for screening flies' complex attributes and behavioral patterns.

Authors

  • Joan Savall
    James H. Clark Center, Stanford University, Stanford, California, USA.
  • Eric Tatt Wei Ho
    James H. Clark Center, Stanford University, Stanford, California, USA.
  • Cheng Huang
    James H. Clark Center, Stanford University, Stanford, California, USA.
  • Jessica R Maxey
    James H. Clark Center, Stanford University, Stanford, California, USA.
  • Mark J Schnitzer
    James H. Clark Center, Stanford University, Stanford, California, USA.

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