Computational identification of piRNA targets on mouse mRNAs.

Journal: Bioinformatics (Oxford, England)
Published Date: Apr 15, 2016

Abstract

MOTIVATION: PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that are highly abundant in the germline. One important role of piRNAs is to defend genome integrity by guiding PIWI proteins to silence transposable elements (TEs), which have a high potential to cause deleterious effects on their host. The mechanism of piRNA-mediated post-transcriptional silencing was also observed to affect mRNAs, suggesting that piRNAs might play a broad role in gene expression regulation. However, there has been no systematic report with regard to how many protein-coding genes might be targeted and regulated by piRNAs.

Authors

  • Jiao Yuan
    Key Laboratory of the Zoological Systematics and Evolution, Institute of Zoology and CAS Key Laboratory of Rna Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  • Peng Zhang
    Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, Shaanxi 710062, China.
  • Ya Cui
    CAS Key Laboratory of Rna Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  • Jiajia Wang
    Department of Obstetrics and Gynecology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
  • Geir Skogerbø
    CAS Key Laboratory of Rna Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  • Da-Wei Huang
    Key Laboratory of the Zoological Systematics and Evolution, Institute of Zoology and.
  • Runsheng Chen
    CAS Key Laboratory of Rna Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  • Shunmin He
    Key Laboratory of the Zoological Systematics and Evolution, Institute of Zoology and.

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