AIMC Topic: RNA, Small Interfering

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rbpTransformer: A novel deep learning model for prediction of piRNA and mRNA bindings.

PloS one Jun 25, 2025
An important issue in biotechnology is predicting whether a piRNA and an mRNA will or will not bind. Research and treatment of diseases, drug discovery, and the silencing and regulation of genes, transposons, and genomic stability may all benefit fro...
Humans Algorithms RNA, Messenger RNA, Small Interfering Deep Learning Piwi-Interacting RNA Computational Biology
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Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke.

ACS nano Mar 5, 2025
Small interfering RNA (siRNA) targeting the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has emerged as a promising therapeutic strategy to mitigate infarct volume and brain injury following ischemic stroke. However, the cl...
Blood-Brain Barrier Animals Male Nanoparticles Disease Models, Animal Mice, Inbred C57BL Deep Learning Mice Infarction, Middle Cerebral Artery RNA, Small Interfering Infrared Rays Ischemic Stroke NLR Family, Pyrin Domain-Containing 3 Protein
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Machine-learning diagnostics of breast cancer using piRNA biomarkers.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals Mar 4, 2025
BACKGROUND AND OBJECTIVES: Prior studies have shown that small non-coding RNAs (sncRNAs) are associated with cancer occurrence or development. Recently, a newly discovered class of small ncRNAs known as PIWI-interacting RNAs (piRNAs) have been found ...
Piwi-Interacting RNA Logistic Models RNA, Small Interfering Humans Machine Learning Female Breast Neoplasms Biomarkers, Tumor
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Mammalian piRNA target prediction using a hierarchical attention model.

BMC bioinformatics Feb 11, 2025
BACKGROUND: Piwi-interacting RNAs (piRNAs) are well established for monitoring and protecting the genome from transposons in germline cells. Recently, numerous studies provided evidence that piRNAs also play important roles in regulating mRNA transcr...
Mammals Piwi-Interacting RNA Animals Deep Learning Computational Biology RNA, Small Interfering Mice Humans
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LKLPDA: A Low-Rank Fast Kernel Learning Approach for Predicting piRNA-Disease Associations.

IEEE/ACM transactions on computational biology and bioinformatics Dec 10, 2024
Piwi-interacting RNAs (piRNAs) are increasingly recognized as potential biomarkers for various diseases. Investig-ating the complex relationship between piRNAs and diseases through computational methods can reduce the costs and risks associated with ...
Piwi-Interacting RNA Computational Biology RNA, Small Interfering Humans Algorithms Genetic Predisposition to Disease Machine Learning
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Representation of non-coding RNA-mediated regulation of gene expression using the Gene Ontology.

RNA biology Oct 7, 2024
Regulatory non-coding RNAs (ncRNAs) are increasingly recognized as integral to the control of biological processes. This is often through the targeted regulation of mRNA expression, but this is by no means the only mechanism through which regulatory ...
RNA, Long Noncoding RNA, Small Interfering Gene Expression Regulation Computational Biology MicroRNAs RNA, Untranslated Molecular Sequence Annotation Gene Ontology Humans Animals
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Mitigating off-target effects of small RNAs: conventional approaches, network theory and artificial intelligence.

British journal of pharmacology Sep 18, 2024
Three types of highly promising small RNA therapeutics, namely, small interfering RNAs (siRNAs), microRNAs (miRNAs) and the RNA subtype of antisense oligonucleotides (ASOs), offer advantages over small-molecule drugs. These small RNAs can target any ...
Oligonucleotides, Antisense Animals MicroRNAs RNA, Small Interfering Humans Artificial Intelligence
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piRNA in Machine-Learning-Based Diagnostics of Colorectal Cancer.

Molecules (Basel, Switzerland) Sep 11, 2024
Objective biomarkers are crucial for early diagnosis to promote treatment and raise survival rates for diseases. With the smallest non-coding RNAs-piwi-RNAs (piRNAs)-and their transcripts, we sought to identify if these piRNAs could be used as biomar...
Colorectal Neoplasms Biomarkers, Tumor RNA, Small Interfering Piwi-Interacting RNA Bayes Theorem Machine Learning Algorithms Humans
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Cm-siRPred: Predicting chemically modified siRNA efficiency based on multi-view learning strategy.

International journal of biological macromolecules Mar 7, 2024
The rational modification of siRNA molecules is crucial for ensuring their drug-like properties. Machine learning-based prediction of chemically modified siRNA (cm-siRNA) efficiency can significantly optimize the design process of siRNA chemical modi...
RNA, Small Interfering Machine Learning Algorithms
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LSTM4piRNA: Efficient piRNA Detection in Large-Scale Genome Databases Using a Deep Learning-Based LSTM Network.

International journal of molecular sciences Oct 27, 2023
Piwi-interacting RNAs (piRNAs) are a new class of small, non-coding RNAs, crucial in the regulation of gene expression. Recent research has revealed links between piRNAs, viral defense mechanisms, and certain human cancers. Due to their clinical pote...
RNA, Small Interfering RNA, Small Untranslated Deep Learning Piwi-Interacting RNA Sequence Analysis, RNA Humans Algorithms
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