canSAR: an updated cancer research and drug discovery knowledgebase.

Journal: Nucleic acids research
Published Date:

Abstract

canSAR (http://cansar.icr.ac.uk) is a publicly available, multidisciplinary, cancer-focused knowledgebase developed to support cancer translational research and drug discovery. canSAR integrates genomic, protein, pharmacological, drug and chemical data with structural biology, protein networks and druggability data. canSAR is widely used to rapidly access information and help interpret experimental data in a translational and drug discovery context. Here we describe major enhancements to canSAR including new data, improved search and browsing capabilities, new disease and cancer cell line summaries and new and enhanced batch analysis tools.

Authors

  • Joseph E Tym
    All authors: The Institute of Cancer Research, London, United Kingdom.
  • Costas Mitsopoulos
    Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.
  • Elizabeth A Coker
    All authors: The Institute of Cancer Research, London, United Kingdom.
  • Parisa Razaz
    Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.
  • Amanda C Schierz
    Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.
  • Albert A Antolin
    Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.
  • Bissan Al-Lazikani
    All authors: The Institute of Cancer Research, London, United Kingdom.