Analysis of Important Gene Ontology Terms and Biological Pathways Related to Pancreatic Cancer.

Journal: BioMed research international
Published Date: Nov 9, 2016

Abstract

Pancreatic cancer is a serious disease that results in more than thirty thousand deaths around the world per year. To design effective treatments, many investigators have devoted themselves to the study of biological processes and mechanisms underlying this disease. However, it is far from complete. In this study, we tried to extract important gene ontology (GO) terms and KEGG pathways for pancreatic cancer by adopting some existing computational methods. Genes that have been validated to be related to pancreatic cancer and have not been validated were represented by features derived from GO terms and KEGG pathways using the enrichment theory. A popular feature selection method, minimum redundancy maximum relevance, was employed to analyze these features and extract important GO terms and KEGG pathways. An extensive analysis of the obtained GO terms and KEGG pathways was provided to confirm the correlations between them and pancreatic cancer.

Authors

  • Hang Yin
    Department of Gastroenterology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.
  • ShaoPeng Wang
    School of Life Sciences, Shanghai University, Shanghai 200444, China.
  • Yu-Hang Zhang
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  • Yu-Dong Cai
    College of Life Science, Shanghai University, Shanghai, People's Republic of China.
  • Hailin Liu
    Department of Gastroenterology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.

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