A dosimetric comparison of real-time adaptive and non-adaptive radiotherapy: A multi-institutional study encompassing robotic, gimbaled, multileaf collimator and couch tracking.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Published Date:

Abstract

PURPOSE: A study of real-time adaptive radiotherapy systems was performed to test the hypothesis that, across delivery systems and institutions, the dosimetric accuracy is improved with adaptive treatments over non-adaptive radiotherapy in the presence of patient-measured tumor motion.

Authors

  • Emma Colvill
    Radiation Physics Laboratory, University of Sydney, Australia; Northern Sydney Cancer Centre, Royal North Shore Hospital, Australia.
  • Jeremy Booth
    Northern Sydney Cancer Centre, Royal North Shore Hospital, Australia; School of Physics, University of Sydney, Australia.
  • Simeon Nill
    The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK.
  • Martin Fast
    The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK.
  • James Bedford
    The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK.
  • Uwe Oelfke
    The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK.
  • Mitsuhiro Nakamura
    Department of Radiation Oncology and Image-Applied Therapy, Kyoto University, Japan.
  • Per Poulsen
    Danish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Esben Worm
    Aarhus University Hospital, Denmark.
  • Rune Hansen
    Aarhus University Hospital, Denmark.
  • Thomas Ravkilde
    Aarhus University Hospital, Denmark.
  • Jonas Scherman Rydhög
    Radiation Medicine Research Center, Rigshospitalet, Copenhagen, Denmark; Niels Bohr Institute, University of Copenhagen, Denmark.
  • Tobias Pommer
    Radiation Medicine Research Center, Rigshospitalet, Copenhagen, Denmark; Section of Radiotherapy Physics and Engineering, Medical Physics Department, Karolinska University Hospital, Stockholm, Sweden.
  • Per Munck Af Rosenschold
    Radiation Medicine Research Center, Rigshospitalet, Copenhagen, Denmark; Niels Bohr Institute, University of Copenhagen, Denmark.
  • Stephanie Lang
    Department of Radiation Oncology, University Hospital Zurich, Switzerland.
  • Matthias Guckenberger
    Department of Radiation Oncology, University Hospital Zurich, Switzerland.
  • Christian Groh
    Department of Radiation Oncology, University Hospital of Würzburg, Germany.
  • Christian Herrmann
    Computer Science Department, Würzburg University, Germany.
  • Dirk Verellen
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Belgium.
  • Kenneth Poels
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Belgium.
  • Lei Wang
    Department of Nursing, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
  • Michael Hadsell
    Radiation Oncology Department, Stanford University, Palo Alto, United States.
  • Thilo Sothmann
    Department for Radiation Oncology, University Clinic Eppendorf, Hamburg, Germany.
  • Oliver Blanck
  • Paul Keall
    Radiation Physics Laboratory, University of Sydney, Australia. Electronic address: paul.keall@sydney.edu.au.