Design of a Coupled Thermoresponsive Hydrogel and Robotic System for Postinfarct Biomaterial Injection Therapy.

Journal: The Annals of thoracic surgery
PMID: 27154150

Abstract

BACKGROUND: In preclinical testing, ventricular wall injection of hydrogels has been shown to be effective in modulating ventricular remodeling and preserving cardiac function. For some approaches, early-stage clinical trials are under way. The hydrogel delivery method varies, with minimally invasive approaches being preferred. Endocardial injections carry a risk of hydrogel regurgitation into the circulation, and precise injection patterning is a challenge. An epicardial approach with a thermally gelling hydrogel through the subxiphoid pathway overcomes these disadvantages.

Authors

  • Yang Zhu
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • Nathan A Wood
  • Kevin Fok
    The Robotics Institute, Carnegie Mellon University, Pittsburgh, Pennsylvania.
  • Tomo Yoshizumi
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • Dae Woo Park
    Heart and Vascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania; Center for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • Hongbin Jiang
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • David S Schwartzman
    Heart and Vascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • Marco A Zenati
    Harvard Medical School and U.S. Dept. of Veterans Affairs, Boston, MA, USA.
  • Takafumi Uchibori
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • William R Wagner
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: wagnerwr@upmc.edu.
  • Cameron N Riviere

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