A unified model based multifactor dimensionality reduction framework for detecting gene-gene interactions.

Journal: Bioinformatics (Oxford, England)
PMID: 27587680

Abstract

MOTIVATION: Gene-gene interaction (GGI) is one of the most popular approaches for finding and explaining the missing heritability of common complex traits in genome-wide association studies. The multifactor dimensionality reduction (MDR) method has been widely studied for detecting GGI effects. However, there are several disadvantages of the existing MDR-based approaches, such as the lack of an efficient way of evaluating the significance of multi-locus models and the high computational burden due to intensive permutation. Furthermore, the MDR method does not distinguish marginal effects from pure interaction effects.

Authors

  • Wenbao Yu
    Department of Statistic, Seoul National University, Seoul, South Korea.
  • Seungyeoun Lee
    Department of Mathematics & Statistics, Sejong University, Seoul, Republic of Korea.
  • Taesung Park
    Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea.

Keywords

External Resources

Popular Topics
Recent Journals