Comprehensive analysis of epigenetically regulated genes in anergic T cells.

Journal: Cellular immunology
PMID: 27839672

Abstract

T cell anergy is one of the important mechanisms for immune tolerance. The results of many studies investigating the mechanism for T cell anergy induction have revealed that the expression of several genes was up-regulated in anergic T cells. It has also been demonstrated that the molecules encoded on those genes played a critical role in anergy induction. However, the mechanism for their up-regulation has not previously been clarified. We examined in this study the changes in gene expression and DNA methylation status caused by anergy induction. Our results demonstrate that the expression of many genes was changed by anergy induction, and that the DNA methylation status of some of these genes was also changed. We show here by a GO analysis that the extent of the change in methylation status caused by anergy induction was distinct between the groups of genes that were categorized.

Authors

  • Yusuke Yoshioka
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo, Japan.
  • Toshinori Kozaki
    Human Resource Development Program in Agricultural Genome Sciences, Tokyo University of Agriculture and Technology, Tokyo, Japan.
  • Kazuo Ishii
    Human Resource Development Program in Agricultural Genome Sciences, Tokyo University of Agriculture and Technology, Tokyo, Japan.
  • Ayano Toyoda
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo, Japan.
  • Makoto Hattori
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo, Japan.
  • Tadashi Yoshida
    Department of Internal Medicine, Hospital Bando, 411 Kutsukake, Bando, Ibaraki 306-0515 Japan.

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