Increased default-mode network centrality in cognitively impaired multiple sclerosis patients.

Journal: Neurology
PMID:

Abstract

OBJECTIVE: To investigate how changes in functional network hierarchy determine cognitive impairment in multiple sclerosis (MS).

Authors

  • Anand J C Eijlers
    Departments of Anatomy and Neurosciences (A.J.C.E., K.A.M., T.M.W., M.D.S., J.J.G.G., M.M.S.), Neurology (M.D.S., B.M.J.U.), and Radiology and Nuclear Medicine (F.B., A.M.W.), Neuroscience Campus Amsterdam, MS Center Amsterdam, VU University Medical Center, the Netherlands; and Institutes of Neurology and Healthcare Engineering (F.B.), UCL, London, UK. a.eijlers@vumc.nl.
  • Kim A Meijer
    Departments of Anatomy and Neurosciences (A.J.C.E., K.A.M., T.M.W., M.D.S., J.J.G.G., M.M.S.), Neurology (M.D.S., B.M.J.U.), and Radiology and Nuclear Medicine (F.B., A.M.W.), Neuroscience Campus Amsterdam, MS Center Amsterdam, VU University Medical Center, the Netherlands; and Institutes of Neurology and Healthcare Engineering (F.B.), UCL, London, UK.
  • Thomas M Wassenaar
    Departments of Anatomy and Neurosciences (A.J.C.E., K.A.M., T.M.W., M.D.S., J.J.G.G., M.M.S.), Neurology (M.D.S., B.M.J.U.), and Radiology and Nuclear Medicine (F.B., A.M.W.), Neuroscience Campus Amsterdam, MS Center Amsterdam, VU University Medical Center, the Netherlands; and Institutes of Neurology and Healthcare Engineering (F.B.), UCL, London, UK.
  • Martijn D Steenwijk
    Departments of Anatomy and Neurosciences (A.J.C.E., K.A.M., T.M.W., M.D.S., J.J.G.G., M.M.S.), Neurology (M.D.S., B.M.J.U.), and Radiology and Nuclear Medicine (F.B., A.M.W.), Neuroscience Campus Amsterdam, MS Center Amsterdam, VU University Medical Center, the Netherlands; and Institutes of Neurology and Healthcare Engineering (F.B.), UCL, London, UK.
  • Bernard M J Uitdehaag
    Departments of Anatomy and Neurosciences (A.J.C.E., K.A.M., T.M.W., M.D.S., J.J.G.G., M.M.S.), Neurology (M.D.S., B.M.J.U.), and Radiology and Nuclear Medicine (F.B., A.M.W.), Neuroscience Campus Amsterdam, MS Center Amsterdam, VU University Medical Center, the Netherlands; and Institutes of Neurology and Healthcare Engineering (F.B.), UCL, London, UK.
  • Frederik Barkhof
    MS Center Amsterdam, Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands.
  • Alle M Wink
    Departments of Anatomy and Neurosciences (A.J.C.E., K.A.M., T.M.W., M.D.S., J.J.G.G., M.M.S.), Neurology (M.D.S., B.M.J.U.), and Radiology and Nuclear Medicine (F.B., A.M.W.), Neuroscience Campus Amsterdam, MS Center Amsterdam, VU University Medical Center, the Netherlands; and Institutes of Neurology and Healthcare Engineering (F.B.), UCL, London, UK.
  • Jeroen J G Geurts
    Departments of Anatomy and Neurosciences (A.J.C.E., K.A.M., T.M.W., M.D.S., J.J.G.G., M.M.S.), Neurology (M.D.S., B.M.J.U.), and Radiology and Nuclear Medicine (F.B., A.M.W.), Neuroscience Campus Amsterdam, MS Center Amsterdam, VU University Medical Center, the Netherlands; and Institutes of Neurology and Healthcare Engineering (F.B.), UCL, London, UK.
  • Menno M Schoonheim
    MS Center Amsterdam, Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands.