AIMC Topic: Neural Pathways
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Assessing changes in whole-brain structural connectivity in the unilateral 6-hydroxydopamine rat model of Parkinson's disease using diffusion imaging and tractography.
Journal of neural engineering
Jul 7, 2025
Parkinson's disease (PD) is a multifactorial, progressive neurodegenerative disease that has a profound impact on those it afflicts. Its hallmark pathophysiology is characterized by degeneration of dopaminergic (DA) neurons in the midbrain which trig...
Brain-wide input-output analysis of tuberal nucleus somatostatin neurons reveals hierarchical circuits for orchestrating feeding behavior.
Nature communications
Jul 1, 2025
Feeding is an innate behavior critical for survival but is also influenced by many non-nutritional factors such as emotion, social context and environmental conditions. Recently, tuberal nucleus somatostatin (SST) neurons have been identified as a ke...
BrainTract: segmentation of white matter fiber tractography and analysis of structural connectivity using hybrid convolutional neural network.
Neuroscience
Jun 19, 2025
Tractography uses diffusion Magnetic Resonance Imaging (dMRI) to noninvasively reconstruct brain white matter (WM) tracts, with Convolutional Neural Network (CNNs) like U-Net significantly advancing accuracy in medical image segmentation. This work p...
Differences in resting-state functional connectivity between depressed bipolar and major depressive disorder patients: A machine learning study.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Jun 17, 2025
Nearly 60 % of individuals with bipolar disorder (BD) are initially classified as major depressive disorder (MDD) patients, resulting in inappropriate drug treatment. Identifying reliable biomarkers for the differential diagnosis between MDD and BD p...
Functional connectome-based predictive modeling of suicidal ideation.
Journal of affective disorders
May 27, 2025
Suicide represents an egregious threat to society despite major advancements in medicine, in part due to limited knowledge of the biological mechanisms of suicidal behavior. We apply a connectome predictive modeling machine learning approach to ident...
Cortical-subcortical neural networks for motor learning and storing sequence memory.
Neural networks : the official journal of the International Neural Network Society
May 7, 2025
Motor sequence learning relies on the synergistic collaboration of multiple brain regions. However, most existing models for motor sequence learning primarily focus on functional-level analyses of sequence memory mechanisms, providing limited neuroph...
Brain circuits that regulate social behavior.
Molecular psychiatry
Apr 26, 2025
Social interactions are essential for the survival of individuals and the reproduction of populations. Social stressors, such as social defeat and isolation, can lead to emotional disorders and cognitive impairments. Furthermore, dysfunctional social...
Altered static and dynamic functional network connectivity and combined Machine learning in asthma.
Neuroscience
Apr 26, 2025
Asthma is a reversible disease characterized by airflow limitation and chronic airway inflammation. Previous neuroimaging studies have shown structural and functional abnormalities in the brains of individuals with asthma. However, earlier research h...
Associations among white matter microstructural changes and the development of emotional reactivity and regulation in infancy.
Molecular psychiatry
Apr 23, 2025
Deficits in emotional reactivity and regulation assessed in infancy, including high levels of negative emotionality (NE), low positive emotionality (PE) and low soothability, can predict future affective and behavioral disorders. White matter (WM) tr...
Alterations in static and dynamic functional network connectivity in chronic low back pain: a resting-state network functional connectivity and machine learning study.
Neuroreport
Apr 9, 2025
Low back pain (LBP) is a prevalent pain condition whose persistence can lead to changes in the brain regions responsible for sensory, cognitive, attentional, and emotional processing. Previous neuroimaging studies have identified various structural a...
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