Therapeutic indications and other use-case-driven updates in the drug ontology: anti-malarials, anti-hypertensives, opioid analgesics, and a large term request.

Journal: Journal of biomedical semantics
Published Date: Mar 3, 2017

Abstract

BACKGROUND: The Drug Ontology (DrOn) is an OWL2-based representation of drug products and their ingredients, mechanisms of action, strengths, and dose forms. We originally created DrOn for use cases in comparative effectiveness research, primarily to identify historically complete sets of United States National Drug Codes (NDCs) that represent packaged drug products, by the ingredient(s), mechanism(s) of action, and so on contained in those products. Although we had designed DrOn from the outset to carefully distinguish those entities that have a therapeutic indication from those entities that have a molecular mechanism of action, we had not previously represented in DrOn any particular therapeutic indication.

Authors

  • William R Hogan
    Department of Health Outcomes and Biomedical Informatics.
  • Josh Hanna
    Biomedical Informatics Program, Department of Health Outcomes and Policy, University of Florida, Gainesville, FL USA.
  • Amanda Hicks
    Department of Health Outcomes and Policy, University of Florida, Gainesville, FL, USA. aehicks@ufl.edu.
  • Samira Amirova
    Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA.
  • Baxter Bramblett
    Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA.
  • Matthew Diller
    Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA.
  • Rodel Enderez
    Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA.
  • Timothy Modzelewski
    Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA.
  • Mirela Vasconcelos
    Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA.
  • Chris Delcher
    Department of Health Outcomes and Policy, University of Florida, Clinical and Translational Research Building, 2004 Mowry Road, P.O. Box 100219, Gainesville, FL, 32610, USA.

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