A disease similarity matrix based on the uniqueness of shared genes.

Journal: BMC medical genomics
Published Date: May 24, 2017

Abstract

BACKGROUND: Complex diseases involve many genes, and these genes are often associated with several different illnesses. Disease similarity measurement can be based on shared genotype or phenotype. Quantifying relationships between genes can reveal previously unknown connections and form a reference base for therapy development and drug repurposing.

Authors

  • Matthew B Carson
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Dr, Suite 1400, Chicago, IL, 60611, USA.
  • Cong Liu
    Department of Bioengineering, University of Illinois at Chicago, 851 S Morgan St, Chicago, IL, 60607, USA.
  • Yao Lu
    Department of Laboratory Medicine, The First Affiliated Hospital of Ningbo University, Ningbo First Hospital, Ningbo, China.
  • Caiyan Jia
    Department of Computer Science, Beijing Jiaotong University, No.3 Shangyuancun, Haidian District, Beijing, 100044, China.
  • Hui Lu
    Key Laboratory of the plateau of environmental damage control, Lanzhou General Hospital of Lanzhou Military Command, Lanzhou, China.

Keywords

External Resources

Popular Topics
Recent Journals