NFPscanner: a webtool for knowledge-based deciphering of biomedical networks.

Journal: BMC bioinformatics
Published Date:

Abstract

BACKGROUND: Many biological pathways have been created to represent different types of knowledge, such as genetic interactions, metabolic reactions, and gene-regulating and physical-binding relationships. Biologists are using a wide range of omics data to elaborately construct various context-specific differential molecular networks. However, they cannot easily gain insight into unfamiliar gene networks with the tools that are currently available for pathways resource and network analysis. They would benefit from the development of a standardized tool to compare functions of multiple biological networks quantitatively and promptly.

Authors

  • Wenjian Xu
    Department of Biotechnology, Beijing Institute of Radiation Medicine, 27 Taiping Street, Haidian District, Beijing, 100850, China.
  • Yang Cao
    Tianjin Institute of Health & Environmental Medicine, 1 Dali Road, Heping District, Tianjin, 300050, China.
  • Ziwei Xie
    Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, 430074, Hubei, China.
  • Haochen He
    Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.
  • Song He
    Department of Biotechnology, Beijing Institute of Radiation Medicine, 27 Taiping Street, Haidian District, Beijing, 100850, China.
  • Hao Hong
  • Xiaochen Bo
    Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.
  • Fei Li
    Institute for Precision Medicine, Tsinghua University, Beijing, China.