Prediction of Anti-VEGF Treatment Requirements in Neovascular AMD Using a Machine Learning Approach.

Journal: Investigative ophthalmology & visual science
PMID:

Abstract

PURPOSE: The purpose of this study was to predict low and high anti-VEGF injection requirements during a pro re nata (PRN) treatment, based on sets of optical coherence tomography (OCT) images acquired during the initiation phase in neovascular AMD.

Authors

  • Hrvoje Bogunović
    Christian Doppler Laboratory for Ophthalmic Image Analysis (OPTIMA), Department of Ophthalmology, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.
  • Sebastian M Waldstein
    Christian Doppler Laboratory for Ophthalmic Image Analysis (OPTIMA), Department of Ophthalmology, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.
  • Thomas Schlegl
    Christian Doppler Laboratory for Ophthalmic Image Analysis, Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
  • Georg Langs
    Department of Biomedical Imaging and Image-guided Therapy Computational Imaging Research Lab, Medical University of Vienna Vienna Austria.
  • Amir Sadeghipour
    Christian Doppler Laboratory for Ophthalmic Image Analysis, Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
  • Xuhui Liu
    Christian Doppler Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria 3Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Bianca S Gerendas
    Christian Doppler Laboratory for Ophthalmic Image Analysis (OPTIMA), Department of Ophthalmology, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.
  • Aaron Osborne
    Genentech, Inc, South San Francisco, California.
  • Ursula Schmidt-Erfurth
    Christian Doppler Laboratory for Ophthalmic Image Analysis (OPTIMA), Department of Ophthalmology, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.