Deciphering complex antibiotic resistance patterns in through whole genome sequencing and machine learning.

Journal: Frontiers in cellular and infection microbiology
PMID: 38379956

Abstract

INTRODUCTION: Helicobacter pylori (H.pylori, Hp) affects billions of people worldwide. However, the emerging resistance of Hp to antibiotics challenges the effectiveness of current treatments. Investigating the genotype-phenotype connection for Hp using next-generation sequencing could enhance our understanding of this resistance.

Authors

  • Jianwei Yu
    Department of Gastroenterology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China.
  • Yan Jia
    Department of Gastroenterology, the 7Medical Center of PLA General Hospital, Beijing, China.
  • Qichao Yu
    Center for Systems Biology, Intelliphecy, Main Building, Beishan Industrial Zone, Shenzhen, Guangdong, China.
  • Lan Lin
    Department of Gastroenterology, Xiamen Humanity Hospital, Xiamen, Fujian, China.
  • Chao Li
    McGill University Health Centre, McGill Adult Unit for Congenital Heart Disease Excellence, Montreal, Québec, Canada.
  • Bowang Chen
    Center for Systems Biology, Intelliphecy, Main Building, Beishan Industrial Zone, Shenzhen, Guangdong, China.
  • Pingyu Zhong
    Department of Gastroenterology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China.
  • Xueqing Lin
    Department of Gastroenterology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China.
  • Huilan Li
    Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China.
  • Yinping Sun
    Department of Gastroenterology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China.
  • Xuejing Zhong
    Department of Science and Education, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China.
  • Yuqi He
    Department of Gastroenterology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
  • Xiaoyun Huang
    Center for Systems Biology, Intelliphecy, Main Building, Beishan Industrial Zone, Shenzhen, Guangdong, China.
  • Shuangming Lin
    Department of Gastrointestinal Surgery, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China.
  • Yuanming Pan
    Cancer Research Center, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.

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