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Clarithromycin

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Deciphering complex antibiotic resistance patterns in through whole genome sequencing and machine learning.

Frontiers in cellular and infection microbiology
INTRODUCTION: Helicobacter pylori (H.pylori, Hp) affects billions of people worldwide. However, the emerging resistance of Hp to antibiotics challenges the effectiveness of current treatments. Investigating the genotype-phenotype connection for Hp us...

Prospective evaluation of clarithromycin in recurrent chronic rhinosinusitis with nasal polyps.

Brazilian journal of otorhinolaryngology
INTRODUCTION: The antiinflammatory effects of macrolides, especially clarithromycin, have been described in patients with chronic rhinosinusitis without polyps and also other chronic inflammatory airway diseases. There is no consensus in the literatu...

A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori.

Signal transduction and targeted therapy
Helicobacter pylori (H. pylori) is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis, and its high prevalence and resistance make it difficult to tackle. A graph neural network-based deep learning model, ...