Integrated prediction of lesion-specific ischaemia from quantitative coronary CT angiography using machine learning: a multicentre study.

Journal: European radiology
Published Date:

Abstract

OBJECTIVES: We aimed to investigate if lesion-specific ischaemia by invasive fractional flow reserve (FFR) can be predicted by an integrated machine learning (ML) ischaemia risk score from quantitative plaque measures from coronary computed tomography angiography (CTA).

Authors

  • Damini Dey
    Departments of Imaging and Medicine, and Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Taper A238, Los Angeles, CA, 90048, USA.
  • Sara Gaur
    Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
  • Kristian A Ovrehus
    Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
  • Piotr J Slomka
    Department of Imaging, Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California Piotr.Slomka@cshs.org.
  • Julian Betancur
    Department of Imaging, Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
  • Markus Goeller
    Biomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Taper building, A238, 8700 Beverly Blvd, Los Angeles, 90048, USA.
  • Michaela M Hell
    Department of Cardiology, Friedrich-Alexander Universitat Erlangen-Nurnberg, Erlangen, Germany.
  • Heidi Gransar
    Departments of Imaging, Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
  • Daniel S Berman
    Departments of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Stephan Achenbach
    Department of Cardiology, Friedrich-Alexander Universitat Erlangen-Nurnberg, Erlangen, Germany.
  • Hans Erik Botker
    Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
  • Jesper Moller Jensen
    Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
  • Jens Flensted Lassen
    Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
  • Bjarne Linde Norgaard
    Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.