Fuzzy set-based generalized multifactor dimensionality reduction analysis of gene-gene interactions.

Journal: BMC medical genomics
PMID: 29697366

Abstract

BACKGROUND: Gene-gene interactions (GGIs) are a known cause of missing heritability. Multifactor dimensionality reduction (MDR) is one of most commonly used methods for GGI detection. The generalized multifactor dimensionality reduction (GMDR) method is an extension of MDR method that is applicable to various types of traits, and allows covariate adjustments. Our previous Fuzzy MDR (FMDR) is another extension for overcoming simple binary classification. FMDR uses continuous member-ship values instead of binary membership values 0 and 1, improving power for detecting causal SNPs and more intuitive interpretations in real data analysis. Here, we propose the fuzzy generalized multifactor dimensionality reduction (FGMDR) method, as a combined analysis of fuzzy set-based analysis and GMDR method, to detect GGIs associated with diseases using fuzzy set theory.

Authors

  • Hye-Young Jung
    Faculty of Liberal Education, Seoul National University, Seoul, 08826, South Korea. Electronic address: hyjunglove@snu.ac.kr.
  • Sangseob Leem
    Department of Statistics, Seoul National University, Seoul, 08826, South Korea. Electronic address: leemss@snu.ac.kr.
  • Taesung Park
    Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea.

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