Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data.

Journal: Arthritis & rheumatology (Hoboken, N.J.)
Published Date:

Abstract

OBJECTIVE: In this study, we sought to refine histologic scoring of rheumatoid arthritis (RA) synovial tissue by training with gene expression data and machine learning.

Authors

  • Dana E Orange
    Hospital for Special Surgery, The Rockefeller University, and New York Genome Center, New York, New York.
  • Phaedra Agius
    New York Genome Center, New York, New York.
  • Edward F DiCarlo
    Hospital for Special Surgery, New York, New York.
  • Nicolas Robine
    New York Genome Center, New York, New York.
  • Heather Geiger
    New York Genome Center, New York, New York.
  • Jackie Szymonifka
    Department of Biostatistics, New York University, New York, NY, USA.
  • Michael McNamara
    Hospital for Special Surgery, New York, New York.
  • Ryan Cummings
    Hospital for Special Surgery, New York, New York.
  • Kathleen M Andersen
    Hospital for Special Surgery, New York, New York.
  • Serene Mirza
    Hospital for Special Surgery, New York, New York.
  • Mark Figgie
    Hospital for Special Surgery, New York, New York.
  • Lionel B Ivashkiv
    Hospital for Special Surgery, New York, New York.
  • Alessandra B Pernis
    Hospital for Special Surgery, New York, New York.
  • Caroline S Jiang
    The Rockefeller University Hospital, New York, New York.
  • Mayu O Frank
    The Rockefeller University and New York Genome Center, New York, New York.
  • Robert B Darnell
    The Rockefeller University and New York Genome Center, New York, New York.
  • Nithya Lingampali
    Stanford University School of Medicine, Stanford, California.
  • William H Robinson
    Stanford University School of Medicine, Stanford, California.
  • Ellen Gravallese
    University of Massachusetts Memorial Medical Center, Worcester.
  • Vivian P Bykerk
    Hospital for Special Surgery, New York, New York.
  • Susan M Goodman
    Hospital for Special Surgery, New York, New York.
  • Laura T Donlin
    Hospital for Special Surgery, New York, New York.