AIMC Topic: Arthritis, Rheumatoid
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Serum tryptophan-kynurenine metabolites served as biomarkers of disease activity in rheumatoid arthritis and linked to immune imbalance.
Arthritis research & therapy
Jul 5, 2025
BACKGROUND: Immune imbalance caused by imbalanced helper T(Th)17/regulatory T (Treg) and follicular helper T (Tfh)/follicular regulatory T (Tfr) cells drives the onset of rheumatoid arthritis (RA) fundamentally. Tryptophan (Trp) metabolism is crucial...
A robust machine learning approach to predicting remission and stratifying risk in rheumatoid arthritis patients treated with bDMARDs.
Scientific reports
Jul 4, 2025
Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting millions worldwide, leading to inflammation, joint damage, and reduced quality of life. Although biological disease-modifying antirheumatic drugs (bDMARDs) are effective, they are co...
Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis.
Nature communications
Jul 2, 2025
Approximately 40% of patients with rheumatoid arthritis do not respond to individual biologic therapies, while biomarkers predictive of treatment response are lacking. Here we analyse RNA-sequencing (RNA-Seq) of pre-treatment synovial tissue from the...
Identification of potential pathogenic genes associated with the comorbidity of rheumatoid arthritis and renal fibrosis using bioinformatics and machine learning.
Scientific reports
Jul 1, 2025
This study aimed to identify the potential pathogenic genes associated with the comorbidity of rheumatoid arthritis (RA) and renal fibrosis (RF). Transcriptomic data related to RA and RF were retrieved from the GEO database. Differential expression g...
Shared gene signatures and molecular mechanisms link ankylosing spondylitis and rheumatoid arthritis.
Scientific reports
Jul 1, 2025
Ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are closely related autoimmune diseases with shared mechanisms that remain unclear. This study aims to identify shared molecular signatures and hub genes underlying the co-occurrence of AS and...
Transcriptomic insights into the mechanism of action of telomere-related biomarkers in rheumatoid arthritis.
Frontiers in immunology
May 22, 2025
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune inflammatory disease. The mechanism by which telomeres are involved in the development of RA remains unclear. This study aimed to investigate the relationship between RA and telomeres.
RNAcare: integrating clinical data with transcriptomic evidence using rheumatoid arthritis as a case study.
BMC medical genomics
May 21, 2025
BACKGROUND: Gene expression analysis is a crucial tool for uncovering the biological mechanisms that underlie differences between patient subgroups, offering insights that can inform clinical decisions. However, despite its potential, gene expression...
The Role of Artificial Intelligence in the Diagnosis and Management of Rheumatoid Arthritis.
Medicina (Kaunas, Lithuania)
Apr 9, 2025
Artificial intelligence has emerged as a transformative tool in healthcare, offering capabilities such as early diagnosis, personalised treatment, and real-time patient monitoring. In the context of rheumatoid arthritis, a chronic autoimmune disease...
Predicting rheumatoid arthritis in the middle-aged and older population using patient-reported outcomes: insights from the SHARE cohort.
International journal of medical informatics
Apr 8, 2025
BACKGROUND: In light of global population aging and the increasing prevalence of Rheumatoid Arthritis (RA) with age, strategies are needed to address this public health challenge. Machine learning (ML) may play a vital role in early identification of...
Artificial intelligence to predict treatment response in rheumatoid arthritis and spondyloarthritis: a scoping review.
Rheumatology international
Apr 7, 2025
To analyse the types and applications of artificial intelligence (AI) technologies to predict treatment response in rheumatoid arthritis (RA) and spondyloarthritis (SpA). A comprehensive search in Medline, Embase, and Cochrane databases (up to August...
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