piMGM: incorporating multi-source priors in mixed graphical models for learning disease networks.
Journal:
Bioinformatics (Oxford, England)
Published Date:
Sep 1, 2018
Abstract
MOTIVATION: Learning probabilistic graphs over mixed data is an important way to combine gene expression and clinical disease data. Leveraging the existing, yet imperfect, information in pathway databases for mixed graphical model (MGM) learning is an understudied problem with tremendous potential applications in systems medicine, the problems of which often involve high-dimensional data.