Proposing New RadLex Terms by Analyzing Free-Text Mammography Reports.

Journal: Journal of digital imaging
Published Date:

Abstract

After years of development, the RadLex terminology contains a large set of controlled terms for the radiology domain, but gaps still exist. We developed a data-driven approach to discover new terms for RadLex by mining a large corpus of radiology reports using natural language processing (NLP) methods. Our system, developed for mammography, discovers new candidate terms by analyzing noun phrases in free-text reports to extend the mammography part of RadLex. Our NLP system extracts noun phrases from free-text mammography reports and classifies these noun phrases as "Has Candidate RadLex Term" or "Does Not Have Candidate RadLex Term." We tested the performance of our algorithm using 100 free-text mammography reports. An expert radiologist determined the true positive and true negative RadLex candidate terms. We calculated precision/positive predictive value and recall/sensitivity metrics to judge the system's performance. Finally, to identify new candidate terms for enhancing RadLex, we applied our NLP method to 270,540 free-text mammography reports obtained from three academic institutions. Our method demonstrated precision/positive predictive value of 0.77 (159/206 terms) and a recall/sensitivity of 0.94 (159/170 terms). The overall accuracy of the system is 0.80 (235/293 terms). When we ran our system on the set of 270,540 reports, it found 31,800 unique noun phrases that are potential candidates for RadLex. Our data-driven approach to mining radiology reports can identify new candidate terms for expanding the breast imaging lexicon portion of RadLex and may be a useful approach for discovering new candidate terms from other radiology domains.

Authors

  • Hakan Bulu
    Department of Radiology and Department of Biomedical Data Science, Medical School Office Building (MSOB), Stanford University, 1265 Welch Road, X383, Stanford, CA, 94305-5464, USA.
  • Dorothy A Sippo
    Department of Radiology, Avon Comprehensive Breast Evaluation Center, Massachusetts General Hospital, Wang Ambulatory Care Building, Suite 240, 15 Parkman Street, Boston, MA, 02114, USA. dsippo@mgh.harvard.edu.
  • Janie M Lee
    Department of Radiology, Seattle Cancer Care Alliance, University of Washington, 825 Eastlake Avenue East, Suite G2-600, Seattle, WA, 98109, USA.
  • Elizabeth S Burnside
    Department of Radiology, University of Wisconsin, Madison, WI, United States.
  • Daniel L Rubin
    Department of Biomedical Data Science, Stanford University School of Medicine Medical School Office Building, Stanford CA 94305-5479.