APOLLO 11 Project, Consortium in Advanced Lung Cancer Patients Treated With Innovative Therapies: Integration of Real-World Data and Translational Research.

Journal: Clinical lung cancer
PMID: 38262770

Abstract

INTRODUCTION: Despite several therapeutic efforts, lung cancer remains a highly lethal disease. Novel therapeutic approaches encompass immune-checkpoint inhibitors, targeted therapeutics and antibody-drug conjugates, with different results. Several studies have been aimed at identifying biomarkers able to predict benefit from these therapies and create a prediction model of response, despite this there is a lack of information to help clinicians in the choice of therapy for lung cancer patients with advanced disease. This is primarily due to the complexity of lung cancer biology, where a single or few biomarkers are not sufficient to provide enough predictive capability to explain biologic differences; other reasons include the paucity of data collected by single studies performed in heterogeneous unmatched cohorts and the methodology of analysis. In fact, classical statistical methods are unable to analyze and integrate the magnitude of information from multiple biological and clinical sources (eg, genomics, transcriptomics, and radiomics).

Authors

  • Arsela Prelaj
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy; Electronic, Information e Bio-engeenering, Politecnico di Milano, Milan, Italy.
  • Monica Ganzinelli
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Leonardo Provenzano
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy. Electronic address: Leonardo.provenzano@istitutotumori.mi.it.
  • Laura Mazzeo
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Giuseppe Viscardi
    Oncology Department, Ospedale Monaldi, Azienda Ospedaliera Dei Colli, Napoli, Italy.
  • Giulio Metro
    Oncology Unit, Azienda Ospedaliera Santa Maria della Misercordia, Perugia, Italy.
  • Giulia Galli
    Medical Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
  • Francesco Agustoni
    Medical Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
  • Carminia Maria Della Corte
    Dipartimento di Medicina di Precisione, Università degli Studi della Campania "Luigi Vanvitelli", Napoli, Italy.
  • Andrea Spagnoletti
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Claudia Giani
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Roberto Ferrara
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Claudia Proto
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Marta Brambilla
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Andra Diana Dumitrascu
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Alessandro Inno
    Oncology Department, IRCCS Ospedale Sacro Cuore don Calabria, Verona, Italy.
  • Diego Signorelli
    Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Elio Gregory Pizzutilo
    Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Matteo Brighenti
    Medical Oncology Unit, ASST Ospedale di Cremona, Cremona, Italy.
  • Federica Biello
    Medical Oncology Unit, Azienda Ospedaliero Universitaria Maggiore della Carità, Novara, Italy.
  • Chiara Bennati
    Oncology Unit, Ospedale Santa Maria delle Croci, Ravenna, Italy.
  • Luca Toschi
    Oncology Department, Istituto Clinico Humanitas IRCCS, Milan, Italy.
  • Marco Russano
    Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, Rome, Italy; Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, United Kingdom.
  • Alessio Cortellini
    Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, Rome, Italy.
  • Chiara Catania
    Oncology Department, Humanitas Gavazzeni, Bergamo, Italy.
  • Federica Bertolini
    Oncology Unit, Modena University Hospital, Modena, Italy.
  • Rossana Berardi
    Clinica Oncologica, Università Politecnica delle Marche, AOU delle Marche, Ancona, Italy.
  • Luca Cantini
    Clinica Oncologica, Università Politecnica delle Marche, AOU delle Marche, Ancona, Italy.
  • Federica Pecci
    Clinica Oncologica, Università Politecnica delle Marche, AOU delle Marche, Ancona, Italy.
  • Marianna Macerelli
    Medical Oncology Unit, Azienda Ospedaliero-Universitaria Santa Maria Della Misericordia, Udine, Italy.
  • Rita Emili
    Oncology Unit, Ospedale Santa Maria della Misericordia, Urbino, Italy.
  • Claudia Bareggi
    Oncology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Francesco Verderame
    Oncology Unit, Ospedali Riuniti Villa Sofia Cervello, Potenza, Italy.
  • Antonio Lugini
    Oncology Unit, Azienda Ospedaliera San Giovanni Addolorata, Rome, Italy.
  • Salvatore Pisconti
    Oncology Unit, Ospedale San Giuseppe Moscati, Taranto, Italy.
  • Federica Buzzacchino
    Oncology Unit, Ospedale San Giuseppe Moscati, Taranto, Italy.
  • Michele Aieta
    Oncology Unit, IRCCS CROB, Rionero in Vulture, Italy.
  • Alfredo Tartarone
    Oncology Unit, IRCCS CROB, Rionero in Vulture, Italy.
  • Gianpaolo Spinelli
    UOC Oncologia Territoriale Ausl Latina, Aprilia, Italy.
  • Emanuele Vita
    Oncology Department, Policlinico Universitario Fondazione "A.Gemelli" IRCCS, Rome, Italy.
  • Salvatore Grisanti
    Medical Oncology Unit, ASST Spedali Civili di Breascia, University of Brescia, Brescia, Italy.
  • Francesco Trovò
    Electronic, Information e Bio-engeenering, Politecnico di Milano, Milan, Italy.
  • Pietro Auletta
    IPOP onlus - Associazione Insieme per i Pazienti di Oncologia Polmonare, Milan, Italy.
  • Daniele Lorenzini
    Pathology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Luca Agnelli
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Sabina Sangaletti
    Sperimental Oncology and Molecular Medicine Department, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Francesca Mazzoni
    Azienda ospedaliero-universitaria Careggi, Firenze, Italy.
  • Giuseppina Calareso
    Radiology Department, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Margherita Ruggirello
    Radiology Department, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Gabriella Francesca Greco
    Radiology Department, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Raffaella Vigorito
    Radiology Department, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Mario Occhipinti
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Sara Manglaviti
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Teresa Beninato
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Rita Leporati
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Paolo Ambrosini
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Roberta Serino
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Cecilia Silvestri
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Emanuela Zito
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Alessandra Chiara Laura Pedrocchi
    Electronic, Information e Bio-engeenering, Politecnico di Milano, Milan, Italy.
  • Vanja Miskovic
    Electronic, Information e Bio-engeenering, Politecnico di Milano, Milan, Italy.
  • Filippo de Braud
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Giancarlo Pruneri
    Pathology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Giuseppe Lo Russo
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
  • Carlo Genova
    Medical Oncology Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
  • Andrea Vingiani
    Pathology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.

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