PDRLGB: precise DNA-binding residue prediction using a light gradient boosting machine.

Journal: BMC bioinformatics
Published Date: Dec 31, 2018

Abstract

BACKGROUND: Identifying specific residues for protein-DNA interactions are of considerable importance to better recognize the binding mechanism of protein-DNA complexes. Despite the fact that many computational DNA-binding residue prediction approaches have been developed, there is still significant room for improvement concerning overall performance and availability.

Authors

  • Lei Deng
    1] Center for Brain Inspired Computing Research (CBICR), Department of Precision Instrument, Tsinghua University, Beijing 100084, China [2] Optical Memory National Engineering Research Center, Department of Precision Instrument, Tsinghua University, Beijing 100084, China.
  • Juan Pan
    Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, No. 24 Haping Road, Xiangfang District, Harbin, 150040, PR China.
  • Xiaojie Xu
  • Wenyi Yang
    School of Software, Central South University, Changsha, 410075, China.
  • Chuyao Liu
    School of Software, Central South University, Changsha, 410075, China.
  • Hui Liu
    Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

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