Expression of socially sensitive genes: The multi-ethnic study of atherosclerosis.

Journal: PloS one
PMID: 30973896

Abstract

BACKGROUND: Gene expression may be an important biological mediator in associations between social factors and health. However, previous studies were limited by small sample sizes and use of differing cell types with heterogeneous expression patterns. We use a large population-based cohort with gene expression measured solely in monocytes to investigate associations between seven social factors and expression of genes previously found to be sensitive to social factors.

Authors

  • Kristen M Brown
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Ana V Diez-Roux
    Department of Epidemiology, Dornsife School of Public Health, Drexel University, Philadelphia, Pennsylvania, United States of America.
  • Jennifer A Smith
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Belinda L Needham
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Bhramar Mukherjee
    Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.
  • Erin B Ware
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Yongmei Liu
    Institute of Systems Genetics, Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610000, China.
  • Steven W Cole
    Department of Medicine, Division of Hematology-Oncology, University of California-Los Angeles, Los Angeles, California, United States of America.
  • Teresa E Seeman
    Department of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America.
  • Sharon L R Kardia
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.

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