Identification of D Modification Sites by Integrating Heterogeneous Features in .

Journal: Molecules (Basel, Switzerland)
Published Date: Jan 22, 2019

Abstract

As an abundant post-transcriptional modification, dihydrouridine (D) has been found in transfer RNA (tRNA) from bacteria, eukaryotes, and archaea. Nonetheless, knowledge of the exact biochemical roles of dihydrouridine in mediating tRNA function is still limited. Accurate identification of the position of D sites is essential for understanding their functions. Therefore, it is desirable to develop novel methods to identify D sites. In this study, an ensemble classifier was proposed for the detection of D modification sites in the transcriptome by using heterogeneous features. The jackknife test results demonstrate that the proposed predictor is promising for the identification of D modification sites. It is anticipated that the proposed method can be widely used for identifying D modification sites in tRNA.

Authors

  • Pengmian Feng
    School of Public Health, North China University of Science and Technology, Tangshan, 063000, China.
  • Zhaochun Xu
    Computer Department, Jingdezhen Ceramic University, Jingdezhen, China.
  • Hui Yang
    Department of Neurology, The Second Affiliated Hospital of Guizhou University of Chinese Medicine, Guiyang, China.
  • Hao Lv
    1 Key Laboratory for Neuro-Information of Ministry of Education, School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China , Chengdu, China .
  • Hui Ding
    Medical School, Huanghe Science & Technology University, Zhengzhou 450063, PR China.
  • Li Liu
    Metanotitia Inc., Shenzhen, China.

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