AIMC Topic: Uridine
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DHUpredET: A comparative computational approach for identification of dihydrouridine modification sites in RNA sequence.
Analytical biochemistry
Mar 6, 2025
Laboratory-based detection of D sites is laborious and expensive. In this study, we developed effective machine learning models employing efficient feature encoding methods to identify D sites. Initially, we explored various state-of-the-art feature ...
Deep-m5U: a deep learning-based approach for RNA 5-methyluridine modification prediction using optimized feature integration.
BMC bioinformatics
Nov 19, 2024
BACKGROUND: RNA 5-methyluridine (m5U) modifications play a crucial role in biological processes, making their accurate identification a key focus in computational biology. This paper introduces Deep-m5U, a robust predictor designed to enhance the pre...
m5UMCB: Prediction of RNA 5-methyluridine sites using multi-scale convolutional neural network with BiLSTM.
Computers in biology and medicine
Dec 2, 2023
As a prevalent RNA modification, 5-methyluridine (mU) plays a critical role in diverse biological processes and disease pathogenesis. High-throughput identification of mU typically relies on labor-intensive biochemical experiments using various seque...
RNADSN: Transfer-Learning 5-Methyluridine (mU) Modification on mRNAs from Common Features of tRNA.
International journal of molecular sciences
Nov 4, 2022
One of the most abundant non-canonical bases widely occurring on various RNA molecules is 5-methyluridine (m5U). Recent studies have revealed its influences on the development of breast cancer, systemic lupus erythematosus, and the regulation of stre...
iRNA-m5U: A sequence based predictor for identifying 5-methyluridine modification sites in Saccharomyces cerevisiae.
Methods (San Diego, Calif.)
Apr 18, 2021
The 5-methyluridine (mU)modification plays important roles in a series of biological processes. Accurate identification of mU sites will be helpful to decode its biological functions. Although experimental techniques have been proposed to detect mU, ...
Identification of D Modification Sites by Integrating Heterogeneous Features in .
Molecules (Basel, Switzerland)
Jan 22, 2019
As an abundant post-transcriptional modification, dihydrouridine (D) has been found in transfer RNA (tRNA) from bacteria, eukaryotes, and archaea. Nonetheless, knowledge of the exact biochemical roles of dihydrouridine in mediating tRNA function is s...
Enhancement of Nucleoside Production in Based on Biosynthetic Pathway Analysis.
BioMed research international
Nov 29, 2017
To enhance nucleoside production in , the biosynthetic pathways of purine and pyrimidine nucleosides were constructed and verified. The differential expression analysis showed that , and genes involved in purine nucleotide biosynthesis were signifi...
[Determination of Nucleosides and Nucleobases in Natural, Cultured and Tissue Culture Anoectochilus roxburghii Using LC-MS].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Nov 1, 2015
OBJECTIVE: To establish a method for simultaneous determination of nucleosides and nucleobases in natural, cultured and tissue culture Anoectochilus roxburghii by high performance liquid chromatography-electrospray ionization/ion trap mass spectromet...
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