To enhance nucleoside production in , the biosynthetic pathways of purine and pyrimidine nucleosides were constructed and verified. The differential expression analysis showed that , and genes involved in purine nucleotide biosynthesis were signifi...
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
27356374
OBJECTIVE: To establish a method for simultaneous determination of nucleosides and nucleobases in natural, cultured and tissue culture Anoectochilus roxburghii by high performance liquid chromatography-electrospray ionization/ion trap mass spectromet...
As an abundant post-transcriptional modification, dihydrouridine (D) has been found in transfer RNA (tRNA) from bacteria, eukaryotes, and archaea. Nonetheless, knowledge of the exact biochemical roles of dihydrouridine in mediating tRNA function is s...
The 5-methyluridine (mU)modification plays important roles in a series of biological processes. Accurate identification of mU sites will be helpful to decode its biological functions. Although experimental techniques have been proposed to detect mU, ...
International journal of molecular sciences
36362279
One of the most abundant non-canonical bases widely occurring on various RNA molecules is 5-methyluridine (m5U). Recent studies have revealed its influences on the development of breast cancer, systemic lupus erythematosus, and the regulation of stre...
As a prevalent RNA modification, 5-methyluridine (mU) plays a critical role in diverse biological processes and disease pathogenesis. High-throughput identification of mU typically relies on labor-intensive biochemical experiments using various seque...
BACKGROUND: RNA 5-methyluridine (m5U) modifications play a crucial role in biological processes, making their accurate identification a key focus in computational biology. This paper introduces Deep-m5U, a robust predictor designed to enhance the pre...